proto-oncogene proteins c-kit

Preferred Label : proto-oncogene proteins c-kit;

MeSH definition : A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.;

MeSH synonym : proto oncogene protein c kit; proto oncogene protein kit; proto-oncogene protein c-kit; proto-oncogene protein, kit; proto-oncogene protein kit; p145 c kit; p145 c-kit; p145c kit; p145(c-kit); p145c-kit; receptor, stem cell factor; scf receptor; stem cell factor receptor; c kit protein; cd117 antigens; c-kit receptor; kit proto oncogene protein; c-kit, proto-oncogene proteins; c-kit protein; c kit receptor; cd117 antigen; kit proto-oncogene protein; c-kit, p145; c-kit, proto-oncogene protein; antigens, cd117; proto oncogene proteins c kit;

CISMeF synonym : EC 2.7.1.112;

Registry Number MeSH : EC 2.7.10.1;

Is substance : O;

UNII : EC 2.7.10.1;

Details

Origin ID

D019009;

UMLS CUI

C0072470;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- CD117 [LOINC component]
- CD117 Ag [LOINC component]
- Mast/stem cell growth factor receptor Kit (substance) [SNOMED CT concept]
- lymphocyte antigen cd117 [SNOMED Notion]
Indexing information
- 2B8-BM monoclonal antibody [MeSH Supplementary Concept]
- 4-t-butylphenyl-N-(4-imidazol-1-ylphenyl)sulfonamide [MeSH Supplementary Concept]
- N3-(4-(4-morpholinocyclohexyl)phenyl)-1-(pyridin-2-yl)-1H-1,2,4-triazole-3,5-diamine [MeSH Supplementary Concept]
Record concept(s)
- Proto-Oncogene proteins c-kit [MeSH concept]
Related MeSH Supplementary Concept(s)
- KIT protein, human [MeSH Supplementary Concept]
- Kit protein, mouse [MeSH Supplementary Concept]
- xkrk1 protein, xenopus [MeSH Supplementary Concept]
See also
- piebaldism [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- CD117 [LOINC component]
- CD117 Ag [LOINC component]
- Mast/stem cell growth factor receptor Kit (substance) [SNOMED CT concept]
- lymphocyte antigen cd117 [SNOMED Notion]

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