MeSH definition : Variation in a population's DNA sequence that is detected by determining alterations
in the conformation of denatured DNA fragments. Denatured DNA fragments are allowed
to renature under conditions that prevent the formation of double-stranded DNA and
allow secondary structure to form in single stranded fragments. These fragments are
then run through polyacrylamide gels to detect variations in the secondary structure
that is manifested as an alteration in migration through the gels.;
Variation in a population's DNA sequence that is detected by determining alterations
in the conformation of denatured DNA fragments. Denatured DNA fragments are allowed
to renature under conditions that prevent the formation of double-stranded DNA and
allow secondary structure to form in single stranded fragments. These fragments are
then run through polyacrylamide gels to detect variations in the secondary structure
that is manifested as an alteration in migration through the gels.