MeSH definition : Transforming proteins encoded by erbA oncogenes from the avian erythroblastosis virus.
They are truncated versions of c-erbA, the thyroid hormone receptor (RECEPTORS, THYROID
HORMONE) that have retained both the DNA-binding and hormone-binding domains. Mutations
in the hormone-binding domains abolish the transcriptional activation function. v-erbA
acts as a dominant repressor of c-erbA, inducing transformation by disinhibiting proliferation.;
MeSH synonym : oncogene products v-erba; v-erba proteins; v erba proteins; erba oncogene proteins; oncogene products v erba; oncogene proteins v erbA;
MeSH annotation : IM; coord with specific virus (IM); /drug eff /ultrastruct permitted; DF: note short
X ref;
Transforming proteins encoded by erbA oncogenes from the avian erythroblastosis virus.
They are truncated versions of c-erbA, the thyroid hormone receptor (RECEPTORS, THYROID
HORMONE) that have retained both the DNA-binding and hormone-binding domains. Mutations
in the hormone-binding domains abolish the transcriptional activation function. v-erbA
acts as a dominant repressor of c-erbA, inducing transformation by disinhibiting proliferation.
Allowable qualifiers