Preferred Label : mice, inbred cftr;
MeSH definition : A strain of mice widely studied as a model for cystic fibrosis. These mice are generated
from embryonic stem cells in which the CFTR (cystic fibrosis transmembrane conductance
regulator) gene is inactivated by gene targeting. As a result, all mice have one copy
of this altered gene in all their tissues. Mice homozygous for the disrupted gene
exhibit many features common to young cystic fibrosis patients, including failure
to thrive, meconium ileus, and alteration of mucous and serous glands.;
MeSH synonym : cftr mice, inbred; mouse, cftr; inbred cftr mouse; inbred cftr mice; mouse, inbred cftr; cftr mouse, inbred; mice, cftr; cftr mice; cftr mouse;
MeSH annotation : NIM when exper animal: no qualif; when IM, qualif permitted; used a model for cystic
fibrosis; do not forget also to check tag MICE; NIM with no qualifiers when experimental animal;
Origin ID : D018181;
UMLS CUI : C0206610;
Allowable qualifiers
- Record concept(s)
- See also
- Semantic type(s)
A strain of mice widely studied as a model for cystic fibrosis. These mice are generated
from embryonic stem cells in which the CFTR (cystic fibrosis transmembrane conductance
regulator) gene is inactivated by gene targeting. As a result, all mice have one copy
of this altered gene in all their tissues. Mice homozygous for the disrupted gene
exhibit many features common to young cystic fibrosis patients, including failure
to thrive, meconium ileus, and alteration of mucous and serous glands.
