Preferred Label : immunoglobulin class switching;
MeSH definition : Gene rearrangement of the B-lymphocyte which results in a substitution in the type
of heavy-chain constant region that is expressed. This allows the effector response
to change while the antigen binding specificity (variable region) remains the same.
The majority of class switching occurs by a DNA recombination event but it also can
take place at the level of RNA processing.;
MeSH synonym : class switching; immunoglobulin class switchings; isotype switching; switching, isotype; switchings, immunoglobulin class; class switching, immunoglobulin; class switchings, immunoglobulin; switching, immunoglobulin class; class switchings; switching, class; switchings, class; isotype switchings; switchings, isotype; Ig Class Switching; Class Switching, Ig; Class Switchings, Ig; Ig Class Switchings; Switching, Ig Class; Switchings, Ig Class;
Wikipedia link : https://en.wikipedia.org/wiki/Immunoglobulin class switching;
Origin ID : D017578;
UMLS CUI : C0206071;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Record concept(s)
- See also
- Semantic type(s)
- UMLS correspondences (same concept)
Gene rearrangement of the B-lymphocyte which results in a substitution in the type
of heavy-chain constant region that is expressed. This allows the effector response
to change while the antigen binding specificity (variable region) remains the same.
The majority of class switching occurs by a DNA recombination event but it also can
take place at the level of RNA processing.
