Preferred Label : complement factor I;
MeSH definition : A plasma serine proteinase that cleaves the alpha-chains of C3b and C4b in the presence
of the cofactors COMPLEMENT FACTOR H and C4-binding protein, respectively. It is a
66-kDa glycoprotein that converts C3b to inactivated C3b (iC3b) followed by the release
of two fragments, C3c (150-kDa) and C3dg (41-kDa). It was formerly called KAF, C3bINF,
or enzyme 3b inactivator.;
MeSH synonym : c4b c3b ina; c4b-c3b inactivator, complement; complement c4b-c3b inactivator; c3b inactivator; inactivator, complement c4b-c3b; complement 3b complement 4b inactivator; c4b-c3b-ina; inactivator, c3b; c4bc3bina; complement c4b c3b inactivator; c3b-c4b inactivator; c3b c4b inactivator; inactivator, c3b-c4b; complement 3b-complement 4b inactivator;
Registry Number MeSH : EC 3.4.21.45;
MeSH annotation : do not confuse with FACTOR I see FIBRINOGEN;
Is substance : O;
UNII : EC 3.4.21.45;
Origin ID : D017244;
UMLS CUI : C0110533;
Allowable qualifiers
- Currated CISMeF NLP mapping
- Pharmacological action(s)
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- Semantic type(s)
- UMLS correspondences (same concept)
A plasma serine proteinase that cleaves the alpha-chains of C3b and C4b in the presence
of the cofactors COMPLEMENT FACTOR H and C4-binding protein, respectively. It is a
66-kDa glycoprotein that converts C3b to inactivated C3b (iC3b) followed by the release
of two fragments, C3c (150-kDa) and C3dg (41-kDa). It was formerly called KAF, C3bINF,
or enzyme 3b inactivator.
