MeSH definition : A large increase in oxygen uptake by neutrophils and most types of tissue macrophages
through activation of an NADPH-cytochrome b-dependent oxidase that reduces oxygen
to a superoxide. Individuals with an inherited defect in which the oxidase that reduces
oxygen to superoxide is decreased or absent (GRANULOMATOUS DISEASE, CHRONIC) often
die as a result of recurrent bacterial infections.;
A large increase in oxygen uptake by neutrophils and most types of tissue macrophages
through activation of an NADPH-cytochrome b-dependent oxidase that reduces oxygen
to a superoxide. Individuals with an inherited defect in which the oxidase that reduces
oxygen to superoxide is decreased or absent (GRANULOMATOUS DISEASE, CHRONIC) often
die as a result of recurrent bacterial infections.