MeSH definition : Chimeric molecules resulting from the fusion of recombinant soluble CD4 to the Fc
portion of immunoglobulins. These have potential use in the therapy of AIDS since
they possess both the gp120-binding and HIV-blocking properties of rCD4 as well as
the long plasma half-life and Fc receptor-binding functions of immunoglobulin.;
Chimeric molecules resulting from the fusion of recombinant soluble CD4 to the Fc
portion of immunoglobulins. These have potential use in the therapy of AIDS since
they possess both the gp120-binding and HIV-blocking properties of rCD4 as well as
the long plasma half-life and Fc receptor-binding functions of immunoglobulin.