Preferred Label : rioprostil;
MeSH definition : A synthetic methylprostaglandin E1 analog that reduces gastric acid secretion and
enhances the gastric mucus-bicarbonate barrier. It is effective in the therapy of
gastric ulcers and gives significant protection against NSAID-induced gastric mucosal
damage. The drug also prevents cyclosporin A-induced damage to endocrine and exocrine
pancreatic secretions. It shows a low order of acute toxicity and there is no evidence
of embryotoxicity, fetotoxicity, teratogenicity, or mutagenicity in animal studies.;
MeSH hyponym : RWJ-15927; TR-4698; ORF-15927; TR 4698; TR4698; ORF 15927; ORF15927; RWJ 15927; RWJ15927;
MeSH CAS label : Prost-13-en-9-one, 1,11,16-trihydroxy-16-methyl-, (11alpha,13E)-;
MeSH Related Number : 77287-05-9 (Rioprostil);
Registry Number MeSH : 77287-05-9;
Is substance : O;
UNII : 7JL402PVQR;
InChIKey : SPOAFZKFCYREMW-FWYLUGOYSA-N;
Origin ID : D016630;
UMLS CUI : C0085199;
Allowable qualifiers
- Currated CISMeF NLP mapping
- Pharmacological action(s)
- Record concept(s)
- Semantic type(s)
- UMLS correspondences (same concept)
A synthetic methylprostaglandin E1 analog that reduces gastric acid secretion and
enhances the gastric mucus-bicarbonate barrier. It is effective in the therapy of
gastric ulcers and gives significant protection against NSAID-induced gastric mucosal
damage. The drug also prevents cyclosporin A-induced damage to endocrine and exocrine
pancreatic secretions. It shows a low order of acute toxicity and there is no evidence
of embryotoxicity, fetotoxicity, teratogenicity, or mutagenicity in animal studies.
