Preferred Label : aflatoxin M1;
MeSH definition : A 4-hydroxylated metabolite of AFLATOXIN B1, one of the MYCOTOXINS from ASPERGILLUS
tainted food. It is associated with LIVER damage and cancer resulting from its P450
activation to the epoxide which alkylates DNA. Toxicity depends on the balance of
liver enzymes that activate it (CYTOCHROME P-450) and others that detoxify it (GLUTATHIONE
S TRANSFERASE) (Pharmac Ther 50.443 1991). Primates & rat are sensitive while mouse
and hamster are tolerant (Canc Res 29.236 1969).;
MeSH synonym : 4 hydroxyaflatoxin b1; 4-hydroxyaflatoxin b1; Aflatoxin M(1);
MeSH Hyperonym : aflatoxin M;
MeSH hyponym : aflatoxin M1, cis( -)-Isomer;
MeSH CAS label : Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-9a-hydroxy-4-methoxy-,
(6aR-cis)-;
MeSH Related Number : aflatoxin M1, cis( -)-Isomer; 25325-49-9 (cis( -)-isomer);
Registry Number MeSH : 6795-23-9;
Related CAS MeSH : 25325-49-9 (Aflatoxin M1, cis( -)-Isomer);
MeSH annotation : /antag permitted but consider also ANTITOXINS; DF: AFM1; /antag permitted but consider also ANTITOXINS;
Is substance : O;
Origin ID : D016607;
UMLS CUI : C0085181;
Allowable qualifiers
- Currated CISMeF NLP mapping
- Pharmacological action(s)
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
A 4-hydroxylated metabolite of AFLATOXIN B1, one of the MYCOTOXINS from ASPERGILLUS
tainted food. It is associated with LIVER damage and cancer resulting from its P450
activation to the epoxide which alkylates DNA. Toxicity depends on the balance of
liver enzymes that activate it (CYTOCHROME P-450) and others that detoxify it (GLUTATHIONE
S TRANSFERASE) (Pharmac Ther 50.443 1991). Primates & rat are sensitive while mouse
and hamster are tolerant (Canc Res 29.236 1969).
