aflatoxin B1 - CISMeF

Preferred Label : aflatoxin B1;

MeSH definition : A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1.;

MeSH synonym : Aflatoxin B(1);

MeSH Hyperonym : aflatoxin B;

MeSH hyponym : NSC-529592; aflatoxin B1, (6aR-cis)-Isomer, 3H-Labeled; aflatoxin B1, (6aR-cis)-Isomer, 14C-Labeled; aflatoxin B1, (6aR-cis)-Isomer, 2H-Labeled; aflatoxin B1 dihydrochloride, (6aR-cis)-Isomer; HSDB-3453; aflatoxin B1, cis( ,-)-Isomer; HSDB 3453; HSDB3453; NSC 529592; NSC529592;

MeSH CAS label : Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-4-methoxy-, (6aR-cis)-;

MeSH Related Number : aflatoxin B1, (6aR-cis)-Isomer, 2H-Labeled; aflatoxin B1, (6aR-cis)-Isomer, 3H-Labeled; aflatoxin B1, cis( ,-)-Isomer; aflatoxin B1, (6aR-cis)-Isomer, 14C-Labeled; aflatoxin B1 dihydrochloride, (6aR-cis)-Isomer; 10279-73-9 (cis( -)-isomer); 1162-65-8 (Aflatoxin B1); 43043-21-6 (14C-labeled cpd(6aR-cis)-isomer); 77076-87-0 (2H-labeled cpd(6aR-cis)-isomer); 77076-88-1 (3H-labeled cpd(6aR-cis)-isomer); 84415-24-7 (di-HCl(6aR-cis)-isomer);

Registry Number MeSH : 1162-65-8;

Related CAS MeSH : 77076-88-1 (Aflatoxin B1, (6aR-cis)-Isomer, 3H-Labeled); 10279-73-9 (Aflatoxin B1, cis( ,-)-Isomer); 43043-21-6 (Aflatoxin B1, (6aR-cis)-Isomer, 14C-Labeled); 84415-24-7 (Aflatoxin B1 dihydrochloride, (6aR-cis)-Isomer); 77076-87-0 (Aflatoxin B1, (6aR-cis)-Isomer, 2H-Labeled);

MeSH annotation : /antag permitted but consider also ANTITOXINS; DF: AFB1; /antag permitted but consider also ANTITOXINS;

Codes EINECS : 214-603-3;

Is substance : O;

UNII : 9N2N2Y55MH;

InChIKey : OQIQSTLJSLGHID-WNWIJWBNSA-N;

Details

Origin ID

D016604;

UMLS CUI

C0085180;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Aflatoxin B (substance) [SNOMED CT concept]
- Aflatoxin B1 [LOINC component]
- aflatoxin b [SNOMED Notion]
CISMeF manual mappings
- aflatoxin b1 [Substance BNPC]
Currated CISMeF NLP mapping
- Aflatoxin B1 [NCIt concept]
Pharmacological action(s)
- poisons [MeSH Descriptor]
Record concept(s)
- HSDB-3453 [MeSH concept]
- NSC-529592 [MeSH concept]
- aflatoxin B [MeSH concept]
- aflatoxin B1 [MeSH concept]
- aflatoxin B1 dihydrochloride, (6aR-cis)-Isomer [MeSH concept]
- aflatoxin B1, (6aR-cis)-Isomer, 14C-Labeled [MeSH concept]
- aflatoxin B1, (6aR-cis)-Isomer, 2H-Labeled [MeSH concept]
- aflatoxin B1, (6aR-cis)-Isomer, 3H-Labeled [MeSH concept]
- aflatoxin B1, cis(+,-)-Isomer [MeSH concept]
Related MeSH Supplementary Concept(s)
- 2,3-dihydro-2,3-(N(5)-formyl-2',5',6'-triamino-4-oxo-N(5)-pyrimidyl)-3-hydroxyaflatoxin B(1) [MeSH Supplementary Concept]
- 2,3-dihydro-2,3-dihydroxyaflatoxin B(1) [MeSH Supplementary Concept]
- 2,3-dihydro-2-(N(7)-guanyl)-3-hydroxyaflatoxin B1 [MeSH Supplementary Concept]
- 8,9-dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl-formamido)-9-hydroxyaflatoxin B1 [MeSH Supplementary Concept]
- 8,9-dihydro-8-(S-glutathionyl)-9-hydroxyaflatoxin B1 [MeSH Supplementary Concept]
- 8,9-dihydroxy-8,9-dihydro-aflatoxin B1 [MeSH Supplementary Concept]
- aflatoxin B1-(O-carboxymethyl)oxime [MeSH Supplementary Concept]
- aflatoxin B1-2,3-oxide [MeSH Supplementary Concept]
- aflatoxin B1-8,9-dichloride [MeSH Supplementary Concept]
- aflatoxin B1-8,9-dihydrodiol-Tris buffer complex [MeSH Supplementary Concept]
- aflatoxin B1-DNA adduct [MeSH Supplementary Concept]
- aflatoxin B1-bovine serum albumin [MeSH Supplementary Concept]
- aflatoxin B1-formamidopyrimidine [MeSH Supplementary Concept]
- aflatoxin B1-lysine adduct [MeSH Supplementary Concept]
- aflatoxin-B1-N7-guanine [MeSH Supplementary Concept]
Semantic type(s)
- Hazardous or Poisonous Substance [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- Aflatoxin B1 [LOINC component]
- Aflatoxin B1 [NCIt concept]
- aflatoxin b1 [Substance BNPC]

Keyword's position in hierarchy(ies) :

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