Preferred Label : aphidicolin;
MeSH definition : An antiviral antibiotic produced by Cephalosporium aphidicola and other fungi. It
inhibits the growth of eukaryotic cells and certain animal viruses by selectively
inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA
polymerases. The drug may be useful for controlling excessive cell proliferation in
patients with cancer, psoriasis or other dermatitis with little or no adverse effect
upon non-multiplying cells.;
MeSH hyponym : ICI-69653; NSC-234714; NSC-351140; NSC 351140; NSC351140; NSC 234714; NSC234714; ICI 69653; ICI69653;
Related MeSH term : aphidicolin, (3-S-(3alpha,4beta,4abeta,6aalpha,8alpha,9alpha,11aalpha,11balpha))-Isomer;
MeSH CAS label : 9,15-Cyclo-C,18-dinor-14,15-secoandrostane-4,17-dimethanol, 3,17-dihydroxy-4-methyl-,
(3alpha,4alpha,5alpha,17alpha)-;
MeSH Related Number : aphidicolin, (3-S-(3alpha,4beta,4abeta,6aalpha,8alpha,9alpha,11aalpha,11balpha))-Isomer; 52645-92-8 ((3-S-(3alpha,4beta,4abeta,6aalpha,8alpha,9alpha,11aalpha,11balpha))-isomer);
Registry Number MeSH : 38966-21-1;
Related CAS MeSH : 52645-92-8 (Aphidicolin, (3-S-(3alpha,4beta,4abeta,6aalpha,8alpha,9alpha,11aalpha,11balpha))-Isomer);
Wikipedia link : https://en.wikipedia.org/wiki/Aphidicolin;
Is substance : O;
Origin ID : D016590;
UMLS CUI : C0085171;
Allowable qualifiers
- Pharmacological action(s)
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- Semantic type(s)
An antiviral antibiotic produced by Cephalosporium aphidicola and other fungi. It
inhibits the growth of eukaryotic cells and certain animal viruses by selectively
inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA
polymerases. The drug may be useful for controlling excessive cell proliferation in
patients with cancer, psoriasis or other dermatitis with little or no adverse effect
upon non-multiplying cells.
