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Preferred Label : mice, scid;

MeSH definition : Mice homozygous for the mutant autosomal recessive gene scid which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.;

MeSH synonym : mouse, scid; severe combined immunodeficient mice; scid mice; immunodeficient mice, severe combined; scid mouse;

Related MeSH term : mouse, SCID-hu; Mouse, SCID hu; SCID-hu Mouse; SCID-hu Mice; Mice, SCID-hu; SCID hu Mice;

MeSH annotation : SCID stands for Severe Combined ImmunoDeficiency; NIM when exper animal: no qualif; when IM, qualif permitted; do not forget also to check tag MICE; NIM with no qualifiers when experimental animal;

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Mice homozygous for the mutant autosomal recessive gene scid which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.

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12/05/2025


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