MeSH definition : Tumor suppressor genes located on human chromosome 13 in the region 13q14 and coding
for a family of phosphoproteins with molecular weights ranging from 104 kDa to 115
kDa. One copy of the wild-type Rb gene is necessary for normal retinal development.
Loss or inactivation of both alleles at this locus results in retinoblastoma.;
Tumor suppressor genes located on human chromosome 13 in the region 13q14 and coding
for a family of phosphoproteins with molecular weights ranging from 104 kDa to 115
kDa. One copy of the wild-type Rb gene is necessary for normal retinal development.
Loss or inactivation of both alleles at this locus results in retinoblastoma.
Allowable qualifiers