Preferred Label : receptors, leukocyte-adhesion;
MeSH definition : Family of proteins associated with the capacity of LEUKOCYTES to adhere to each other
and to certain substrata, e.g., the C3bi component of complement. Members of this
family are the LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; (LFA-1), the MACROPHAGE-1
ANTIGEN; (Mac-1), and the INTEGRIN ALPHAXBETA2 or p150,95 leukocyte adhesion protein.
They all share a common beta-subunit which is the CD18 antigen. All three of the above
antigens are absent in inherited LEUKOCYTE-ADHESION DEFICIENCY SYNDROME, which is
characterized by recurrent bacterial infections, impaired pus formation, and wound
healing as well as abnormalities in a wide spectrum of adherence-dependent functions
of granulocytes, monocytes, and lymphoid cells.;
MeSH synonym : leukocyte adhesion receptors; leukocyte adhesion receptor family; leu cam receptor family; leu-cam receptor family; family, leu-cam receptor; leukocyte-adhesion receptor; leukocyte adhesion receptor; receptor, leukocyte-adhesion; leukocyte-adhesion receptor family; receptor family, leu-cam; leukocyte-adhesion receptors; receptors, leukocyte adhesion;
MeSH annotation : /defic: consider LEUKOCYTE-ADHESION DEFICIENCY SYNDROME; DF: RECEPT LEUKOCYTE ADHESION;
Is substance : O;
Origin ID : D016028;
UMLS CUI : C0034822;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Record concept(s)
- See also
- Semantic type(s)
- UMLS correspondences (same concept)
Family of proteins associated with the capacity of LEUKOCYTES to adhere to each other
and to certain substrata, e.g., the C3bi component of complement. Members of this
family are the LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; (LFA-1), the MACROPHAGE-1
ANTIGEN; (Mac-1), and the INTEGRIN ALPHAXBETA2 or p150,95 leukocyte adhesion protein.
They all share a common beta-subunit which is the CD18 antigen. All three of the above
antigens are absent in inherited LEUKOCYTE-ADHESION DEFICIENCY SYNDROME, which is
characterized by recurrent bacterial infections, impaired pus formation, and wound
healing as well as abnormalities in a wide spectrum of adherence-dependent functions
of granulocytes, monocytes, and lymphoid cells.
