Preferred Label : complement C1r;
MeSH definition : A 80-kDa subcomponent of complement C1, existing as a SERINE PROTEASE proenzyme in
the intact complement C1 complex. When COMPLEMENT C1Q is bound to antibodies, the
changed tertiary structure causes autolytic activation of complement C1r which is
cleaved into two chains, A (heavy) and B (light, the serine protease), connected by
disulfide bonds. The activated C1r serine protease, in turn, activates COMPLEMENT
C1S proenzyme by cleaving the Arg426-Ile427 bond. No fragment is released when either
C1r or C1s is cleaved.;
MeSH synonym : complement 1r; c1r, complement; complement component 1r; component 1r, complement; c1r complement; complement, C1r;
Registry Number MeSH : EC 3.4.21.41;
Wikipedia link : https://en.wikipedia.org/wiki/Complement component 1r;
Is substance : O;
UNII : EC 3.4.21.41;
Origin ID : D015923;
UMLS CUI : C0009503;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Pharmacological action(s)
- Record concept(s)
- Semantic type(s)
- UMLS correspondences (same concept)
A 80-kDa subcomponent of complement C1, existing as a SERINE PROTEASE proenzyme in
the intact complement C1 complex. When COMPLEMENT C1Q is bound to antibodies, the
changed tertiary structure causes autolytic activation of complement C1r which is
cleaved into two chains, A (heavy) and B (light, the serine protease), connected by
disulfide bonds. The activated C1r serine protease, in turn, activates COMPLEMENT
C1S proenzyme by cleaving the Arg426-Ile427 bond. No fragment is released when either
C1r or C1s is cleaved.
