complement C1q

Preferred Label : complement C1q;

MeSH definition : A subcomponent of complement C1, composed of six copies of three polypeptide chains (A, B, and C), each encoded by a separate gene (C1QA; C1QB; C1QC). This complex is arranged in nine subunits (six disulfide-linked dimers of A and B, and three disulfide-linked homodimers of C). C1q has binding sites for antibodies (the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M). The interaction of C1q and immunoglobulin activates the two proenzymes COMPLEMENT C1R and COMPLEMENT C1S, thus initiating the cascade of COMPLEMENT ACTIVATION via the CLASSICAL COMPLEMENT PATHWAY.;

MeSH synonym : complement component 1q; c1q, complement; component 1q, complement; c1q complement; complement 1q; complement, C1q;

MeSH CAS label : complement C1q;

Registry Number MeSH : 80295-33-6;

Is substance : O;

Details

Origin ID

D015922;

UMLS CUI

C0009502;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Complement C1q [LOINC component]
- Complement component C1q (substance) [SNOMED CT concept]
- complement component c1q [SNOMED Notion]
Indexing information
- complement 1q receptor [MeSH Supplementary Concept]
Pharmacological action(s)
- immunologic factors [MeSH Descriptor]
Record concept(s)
- complement C1q [MeSH concept]
Related MeSH Supplementary Concept(s)
- C1QA protein, human [MeSH Supplementary Concept]
- C1QL1 protein, human [MeSH Supplementary Concept]
- C1QL3 protein, human [MeSH Supplementary Concept]
- C1qa protein, mouse [MeSH Supplementary Concept]
- C1ql1 protein, mouse [MeSH Supplementary Concept]
- C1ql3 protein, rat [MeSH Supplementary Concept]
- complement C1q-like protein 3, mouse [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- Complement C1q [LOINC component]
- Complement Component C1q [NCIt concept]
- Complement component C1q (substance) [SNOMED CT concept]
- complement component c1q [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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