Preferred Label : deoxyribonucleases, type i site-specific;
MeSH definition : Enzyme systems containing three different subunits and requiring ATP, S-adenosylmethionine,
and magnesium for endonucleolytic activity to give random double-stranded fragments
with terminal 5'-phosphates. They function also as DNA-dependent ATPases and modification
methylases, catalyzing the reactions of EC 2.1.1.72 and EC 2.1.1.73 with similar site-specificity.
The systems recognize specific short DNA sequences and cleave at sites remote from
the recognition sequence. Enzymes from different microorganisms with the same specificity
are called isoschizomers. EC 3.1.21.3.;
MeSH synonym : dnase, site-specific, type i; site specific dnase, type i; type i restriction enzymes; type i site-specific deoxyribonucleases; type i site specific deoxyribonucleases; dna restriction enzymes, type i; site-specific dnase, type i; type i site specific dnase; type i site-specific dnase; restriction endonucleases, type i; dnase, site specific, type i; deoxyribonucleases, type I site specific; deoxyribonucleases, type I, Site-Specific; deoxyribonucleases, type I, site specific;
Registry Number MeSH : EC 3.1.21.3;
MeSH annotation : DF: DNASE SS I;
Wikipedia link : https://en.wikipedia.org/wiki/Deoxyribonucleases, type i site-specific;
Is substance : O;
UNII : EC 3.1.21.3;
Origin ID : D015253;
UMLS CUI : C0011523;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- Semantic type(s)
- UMLS correspondences (same concept)
Enzyme systems containing three different subunits and requiring ATP, S-adenosylmethionine,
and magnesium for endonucleolytic activity to give random double-stranded fragments
with terminal 5'-phosphates. They function also as DNA-dependent ATPases and modification
methylases, catalyzing the reactions of EC 2.1.1.72 and EC 2.1.1.73 with similar site-specificity.
The systems recognize specific short DNA sequences and cleave at sites remote from
the recognition sequence. Enzymes from different microorganisms with the same specificity
are called isoschizomers. EC 3.1.21.3.
