MeSH definition : Class I human histocompatibility (HLA) antigens encoded by a small cluster of structural
genes at the C locus on chromosome 6. They have significantly lower immunogenicity
than the HLA-A and -B determinants and are therefore of minor importance in donor/recipient
crossmatching. Their primary role is their high-risk association with certain disease
manifestations (e.g., spondylarthritis, psoriasis, multiple myeloma).;
Class I human histocompatibility (HLA) antigens encoded by a small cluster of structural
genes at the C locus on chromosome 6. They have significantly lower immunogenicity
than the HLA-A and -B determinants and are therefore of minor importance in donor/recipient
crossmatching. Their primary role is their high-risk association with certain disease
manifestations (e.g., spondylarthritis, psoriasis, multiple myeloma).