25-hydroxyvitamin d3 1-alpha-hydroxylase

Preferred Label : 25-hydroxyvitamin d3 1-alpha-hydroxylase;

MeSH definition : A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).;

MeSH synonym : cyp27b1; cytochrome p 450 cyp27b1; 1-alpha-hydroxylase, 25-hydroxyvitamin d; 1-hydroxylase, 25-hydroxyvitamin d2; 25 hydroxycholecalciferol 1 hydroxylase; 25-hydroxyergocalciferol 1-alpha-hydroxylase; 25-hydroxyvitamin d(3) 1 alpha-hydroxylase; 25 hydroxyergocalciferol 1 alpha hydroxylase; 25-hydroxycholecalciferol-1-hydroxylase; 25-hydroxyvitamin d2 1-hydroxylase; 25 hydroxyvitamin d2 1 hydroxylase; cytochrome p-450 cyp27b1; calcidiol 1-monooxygenase; calcidiol 1 monooxygenase; 25-hydroxyvitamin d 1-alpha-hydroxylase; 25 hydroxyvitamin d 1 alpha hydroxylase; 25-hydroxycholecalciferol 1-hydroxylase; 1-alpha-hydroxylase, 25-hydroxyergocalciferol; 25 hydroxyvitamin D3 1 alpha hydroxylase;

MeSH CAS label : Calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating);

Registry Number MeSH : EC 1.14.-; EC 1.14.13.13;

Is substance : O;

UNII : EC 1.14.15.18;

Details

Origin ID

D015090;

UMLS CUI

C0000340;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- 25-Hydroxyvitamin D-1 Alpha-Hydroxylase, Mitochondrial [NCIt concept]
- Calcidiol 1-monooxygenase (substance) [SNOMED CT concept]
- calcidiol 1-monooxygenase [SNOMED Notion]
Record concept(s)
- 25-Hydroxyvitamin D3 1-alpha-Hydroxylase [MeSH concept]
Related MeSH Supplementary Concept(s)
- CYP27B1 protein, human [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Calcidiol 1-monooxygenase (substance) [SNOMED CT concept]
- calcidiol 1-monooxygenase [SNOMED Notion]

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