uroporphyrinogen iii synthetase

Preferred Label : uroporphyrinogen iii synthetase;

MeSH definition : An enzyme that catalyzes the cyclization of hydroxymethylbilane to yield UROPORPHYRINOGEN III and water. It is the fourth enzyme in the 8-enzyme biosynthetic pathway of HEME, and is encoded by UROS gene. Mutations of UROS gene result in CONGENITAL ERYTHROPOIETIC PORPHYRIA.;

MeSH synonym : cosynthase; cosynthetase, uroporphyrinogen iii; isomerase, uroporphyrinogen; synthase, uroporphyrinogen-iii; synthetase, uroporphyrinogen iii; uroporphyrinogen iii cosynthetase; uroporphyrinogen iii synthase; uroporphyrinogen isomerase; uroporphyrinogen-iii synthase;

MeSH CAS label : hydroxymethylbilane hydro-lyase (cyclizing);

MeSH Related Number : 37340-55-9 (CAS RN);

Registry Number MeSH : EC 4.2.1.75;

Is substance : O;

UNII : EC 4.2.1.75;

Details

Origin ID

D014576;

UMLS CUI

C0042089;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Porphobilinogen deaminase [LOINC component]
- Uroporphyrinogen III synthase [OMIM gene]
- uroporphyrinogen III synthase [ORDO Gene]
- uroporphyrinogen III synthase [HGNC gene]
Indexing information
- 19-bromo-1-hydroxymethylbilane [MeSH Supplementary Concept]
- 19-methyl-1-hydroxymethylbilane [MeSH Supplementary Concept]
Record concept(s)
- uroporphyrinogen III synthetase [MeSH concept]
Related MeSH term(s)
- porphyria, erythropoietic [MeSH Descriptor]
See also
- porphyria, erythropoietic [MeSH Descriptor]
See also inter- (CISMeF)
- Uroporphyrinogen synthase (substance) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Uroporphyrinogen III synthase [LOINC component]
- Uroporphyrinogen-III synthase (substance) [SNOMED CT concept]
- uroporphyrinogen-iii synthase [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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