pyruvate dehydrogenase complex

Preferred Label : pyruvate dehydrogenase complex;

MeSH definition : A multienzyme complex responsible for the formation of ACETYL COENZYME A from pyruvate. The enzyme components are PYRUVATE DEHYDROGENASE (LIPOAMIDE); dihydrolipoamide acetyltransferase; and LIPOAMIDE DEHYDROGENASE. Pyruvate dehydrogenase complex is subject to three types of control: inhibited by acetyl-CoA and NADH; influenced by the energy state of the cell; and inhibited when a specific serine residue in the pyruvate decarboxylase is phosphorylated by ATP. PYRUVATE DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE catalyzes reactivation of the complex. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed);

MeSH synonym : complex, pyruvate dehydrogenase; dehydrogenase complex, pyruvate;

Wikipedia link : https://en.wikipedia.org/wiki/Pyruvate dehydrogenase complex;

Is substance : O;

Details

Origin ID

D011768;

UMLS CUI

C0034344;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- PDHX Gene [NCIt concept]
- pyruvate dehydrogenase complex [GO term]
Currated CISMeF NLP mapping
- Pyruvate dehydrogenase complex [LOINC component]
Indexing information
- bromopyruvate [MeSH Supplementary Concept]
- pyruvate dehydrogenase complex inactivase [MeSH Supplementary Concept]
- thiamine thiazolone [MeSH Supplementary Concept]
- thiamine thiothiazolone pyrophosphate [MeSH Supplementary Concept]
Record concept(s)
- pyruvate dehydrogenase complex [MeSH concept]
Related MeSH Supplementary Concept(s)
- PDHX protein, human [MeSH Supplementary Concept]
- PDX1 protein, S cerevisiae [MeSH Supplementary Concept]
- pyruvate dehydrogenase activator [MeSH Supplementary Concept]
- pyruvate dehydrogenase complex component X, bos taurus [MeSH Supplementary Concept]
- pyruvate dehydrogenase multienzyme complex E1 [MeSH Supplementary Concept]
Related MeSH term(s)
- pyruvate dehydrogenase complex deficiency disease [MeSH Descriptor]
See also
- pyruvate dehydrogenase complex deficiency disease [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Pyruvate dehydrogenase complex [LOINC component]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients