MeSH definition : Atypical gamma immunoglobulins characterized by their irreversible heat denaturation
at 56-degrees C. Pyroprecipitation is inhibited at pH below 3 and above 9. The presence
of pyroglobulins in the serum is the cause of pyroglobulinemia. They are frequently
present in multiple myeloma and the pyroglobulin precipitate binds complement, reacts
with rheumatoid factor, produces passive cutaneous anaphylaxis, generalized passive
anaphylaxis and passive Arthus-type phenomena.;
Atypical gamma immunoglobulins characterized by their irreversible heat denaturation
at 56-degrees C. Pyroprecipitation is inhibited at pH below 3 and above 9. The presence
of pyroglobulins in the serum is the cause of pyroglobulinemia. They are frequently
present in multiple myeloma and the pyroglobulin precipitate binds complement, reacts
with rheumatoid factor, produces passive cutaneous anaphylaxis, generalized passive
anaphylaxis and passive Arthus-type phenomena.