hydroxymethylbilane synthase

Preferred Label : hydroxymethylbilane synthase;

MeSH definition : An enzyme that catalyzes the tetrapolymerization of the monopyrrole PORPHOBILINOGEN into the hydroxymethylbilane preuroporphyrinogen (UROPORPHYRINOGENS) in several discrete steps. It is the third enzyme in the 8-enzyme biosynthetic pathway of HEME. In humans, deficiency in this enzyme encoded by HMBS (or PBGD) gene results in a form of neurological porphyria (PORPHYRIA, ACUTE INTERMITTENT). This enzyme was formerly listed as EC 4.3.1.8;

MeSH synonym : porphobilinogen ammonia-lyase; porphobilinogen deaminase; uroporphyrinogen i synthase; hydroxymethylbilane synthetase; pre-uroporphyrinogen synthetase; synthetase, pre-uroporphyrinogen; pre uroporphyrinogen synthetase; ammonia-lyase, porphobilinogen; synthase, uroporphyrinogen i; synthase, hydroxymethylbilane; porphobilinogen ammonia lyase; deaminase, porphobilinogen; synthetase, hydroxymethylbilane; synthetase, preuroporphyrinogen; preuroporphyrinogen synthetase;

MeSH CAS label : porphobilinogen ammonia-lyase (polymerizing);

MeSH Related Number : 9036-47-9 (CAS RN);

Registry Number MeSH : EC 2.5.1.61;

Wikipedia link : https://en.wikipedia.org/wiki/Hydroxymethylbilane synthase;

Is substance : O;

UNII : EC 2.5.1.61;

Details

Origin ID

D011163;

UMLS CUI

C0032706;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Hydroxymethylbilane synthase [OMIM gene]
- hydroxymethylbilane synthase [HGNC gene]
- hydroxymethylbilane synthase [ORDO Gene]
- hydroxymethylbilane synthase activity [GO term]
- uroporphyrinogen-iii synthase [SNOMED Notion]
Indexing information
- hydroxymethylbilane [MeSH Supplementary Concept]
Record concept(s)
- hydroxymethylbilane synthase [MeSH concept]
Related MeSH Supplementary Concept(s)
- HEMC protein, Arabidopsis [MeSH Supplementary Concept]
- hemC protein, E coli [MeSH Supplementary Concept]
Related MeSH term(s)
- porphyria, acute intermittent [MeSH Descriptor]
See also
- porphyria, acute intermittent [MeSH Descriptor]
- porphyrias [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Hydroxymethylbilane synthase (substance) [SNOMED CT concept]
- Porphobilinogen deaminase [LOINC component]
- Uroporphyrinogen synthase (substance) [SNOMED CT concept]
- porphobilinogen deaminase [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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