MeSH definition : A protein found in bacteria and eukaryotic mitochondria which delivers aminoacyl-tRNA's
to the A site of the ribosome. The aminoacyl-tRNA is first bound to a complex of elongation
factor Tu containing a molecule of bound GTP. The resulting complex is then bound
to the 70S initiation complex. Simultaneously the GTP is hydrolyzed and a Tu-GDP complex
is released from the 70S ribosome. The Tu-GTP complex is regenerated from the Tu-GDP
complex by the Ts elongation factor and GTP.;
MeSH synonym : ef-tu; ef tu; elongation factor tu; factor tu, elongation; protein synthesis elongation factor tu;
A protein found in bacteria and eukaryotic mitochondria which delivers aminoacyl-tRNA's
to the A site of the ribosome. The aminoacyl-tRNA is first bound to a complex of elongation
factor Tu containing a molecule of bound GTP. The resulting complex is then bound
to the 70S initiation complex. Simultaneously the GTP is hydrolyzed and a Tu-GDP complex
is released from the 70S ribosome. The Tu-GTP complex is regenerated from the Tu-GDP
complex by the Ts elongation factor and GTP.