nonsuppressible insulin-like activity

Preferred Label : nonsuppressible insulin-like activity;

MeSH definition : A blood protein (NSILA) which mimics the biological activity of insulin in serum, but is not suppressed by insulin antibodies. During acid-ethanol extraction of Cohn fraction III, 10% of the activity is found in the supernatant (NSILA-S) and the remaining activity in the precipitate (NSILA-P). The latter is a large molecular compound, much less stable than the soluble fraction. NSILA-S is a more potent growth factor than insulin and exhibits sulfation activity.;

MeSH synonym : insulin-like activity, nonsuppressible; nonsuppressible insulinlike activity; activity, nonsuppressible insulin-like; activity, nonsuppressible insulinlike; insulinlike activity, nonsuppressible; nsila; nonsuppressible insulin like activity;

MeSH hyponym : NSILA-P; NSILA-S;

MeSH annotation : note category; a blood protein mimicking blood insulin;

Is substance : O;

Details

Origin ID

D009632;

UMLS CUI

C0028318;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- non-suppressible insulin-like activity [SNOMED Notion]
Indexing information
- nonsuppressible insulin-like carrier protein, human [MeSH Supplementary Concept]
Record concept(s)
- NSILA-P [MeSH concept]
- NSILA-S [MeSH concept]
- nonsuppressible Insulin-Like activity [MeSH concept]
See also
- insulin [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Hormone [UMLS semantic type]
UMLS correspondences (same concept)
- non-suppressible insulin-like activity [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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