Preferred Label : neuritis, autoimmune, experimental;
MeSH definition : An experimental animal model for the demyelinating disease of GUILLAINE-BARRE SYNDROME.
In the most frequently used protocol, animals are injected with a peripheral nerve
tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy
secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2
PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation
of macrophages and T lymphocytes in the peripheral nervous system, similar to that
seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of Neurology,
6th ed, p1314; J Neuroimmunol 1998 Apr 1;84(1):40-52);
MeSH synonym : autoimmune neuritis, experimental; neuritis, experimental autoimmune; experimental allergic neuritis; experimental autoimmune neuropathy; autoimmune neuropathy, experimental; neuropathies, experimental autoimmune; neuritis, experimental allergic; ean (experimental autoimmune neuritis); allergic neuritis, experimental; autoimmune neuropathies, experimental; ean (experimental allergic neuritis); experimental autoimmune neuritis; experimental autoimmune neuropathies; neuropathy, experimental autoimmune;
MeSH annotation : coordinate with GUILLAINE-BARRE SYNDROME if pertinent; DF: NEURITIS EXPER ALLERGIC; coordinate with GUILLAINE-BARRE SYNDROME if pertinent;
Origin ID : D009444;
UMLS CUI : C0027814;
Allowable qualifiers
- Currated CISMeF NLP mapping
- Manual NTBT mappings (CISMeF)
- Record concept(s)
- Semantic type(s)
- UMLS correspondences (same concept)
An experimental animal model for the demyelinating disease of GUILLAINE-BARRE SYNDROME.
In the most frequently used protocol, animals are injected with a peripheral nerve
tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy
secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2
PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation
of macrophages and T lymphocytes in the peripheral nervous system, similar to that
seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of Neurology,
6th ed, p1314; J Neuroimmunol 1998 Apr 1;84(1):40-52)
