Preferred Label : Lewis Blood Group Antigens;
MeSH definition : A group of dominantly and independently inherited antigens associated with the ABO
blood factors. They are glycolipids present in plasma and secretions that may adhere
to the erythrocytes. The phenotype Le(b) is the result of the interaction of the Le
gene Le(a) with the genes for the ABO blood groups.; Carbohydrate antigens structurally related to the ABH BLOOD-GROUP SYSTEM. They may
occur as a modification of saccharide chains on glycolipids or glycoproteins on cell
surfaces or in plasma, or as free oligosaccharides in secretions. Lewis antigens
are not synthesized in blood cells. Instead Lewis glycolipids present in plasma are
absorbed onto the surface of ERYTHROCYTES; LYMPHOCYTES; and PLATELETS. The phenotypes
Le(a) and Le(b) are the result of the actions of two genes the Le gene (fucosyltransferase
FUT3) and the Se gene (fucosyltransferase FUT2) on the precursor carbohydrate, glycolipid
or glycoprotein. Other FUCOSYLTRANSFERASES can also synthesize the Lewis antigens.;
MeSH synonym : blood-group system, lewis; le(a) blood group system; lewis system; lewis blood group system; Lewis Blood-Group System;
CISMeF synonym : lewis Blood-Group system; antigen, le; antigens, le; le antigen; system, lewis; system, lewis blood-group;
MeSH Hyperonym : Antigens, Lewis; Le Antigens;
Related MeSH term : Antigens, Sialyl Lewis; Lewis Blood Group Related Tumor-Associated Antigens; Lewis Blood Group Related Tumor Associated Antigens; Lewis Antigen Related Tumor-Associated Antigens; Lewis Antigen Related Tumor Associated Antigens; Lewis Related Antigens; Antigens, Lewis Related; Blood Group Lewis Related Antigens;
MeSH annotation : IM; coord with disease /blood, not /immunol nor /genet; TN 230; coordinate with disease /blood, not /immunol nor /genet;
Wikipedia link : https://en.wikipedia.org/wiki/Lewis blood-group system;
Origin ID : D007983;
UMLS CUI : C0023595;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Indexing information
- CY 1747 [MeSH Supplementary Concept]
- LX 0104 [MeSH Supplementary Concept]
- cylexin [MeSH Supplementary Concept]
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
A group of dominantly and independently inherited antigens associated with the ABO
blood factors. They are glycolipids present in plasma and secretions that may adhere
to the erythrocytes. The phenotype Le(b) is the result of the interaction of the Le
gene Le(a) with the genes for the ABO blood groups.
Carbohydrate antigens structurally related to the ABH BLOOD-GROUP SYSTEM. They may
occur as a modification of saccharide chains on glycolipids or glycoproteins on cell
surfaces or in plasma, or as free oligosaccharides in secretions. Lewis antigens
are not synthesized in blood cells. Instead Lewis glycolipids present in plasma are
absorbed onto the surface of ERYTHROCYTES; LYMPHOCYTES; and PLATELETS. The phenotypes
Le(a) and Le(b) are the result of the actions of two genes the Le gene (fucosyltransferase
FUT3) and the Se gene (fucosyltransferase FUT2) on the precursor carbohydrate, glycolipid
or glycoprotein. Other FUCOSYLTRANSFERASES can also synthesize the Lewis antigens.
