MeSH definition : Unique genetically-controlled determinants present on ANTIBODIES whose specificity
is limited to a single group of proteins (e.g., another antibody molecule or an individual
myeloma protein). The idiotype appears to represent the antigenicity of the antigen-binding
site of the antibody and to be genetically codetermined with it. The idiotypic determinants
have been precisely located to the IMMUNOGLOBULIN VARIABLE REGION of both immunoglobin
polypeptide chains.;
Unique genetically-controlled determinants present on ANTIBODIES whose specificity
is limited to a single group of proteins (e.g., another antibody molecule or an individual
myeloma protein). The idiotype appears to represent the antigenicity of the antigen-binding
site of the antibody and to be genetically codetermined with it. The idiotypic determinants
have been precisely located to the IMMUNOGLOBULIN VARIABLE REGION of both immunoglobin
polypeptide chains.