Preferred Label : GTP cyclohydrolase;
MeSH definition : (GTP cyclohydrolase I) or GTP 7,8-8,9-dihydrolase (pyrophosphate-forming) (GTP cyclohydrolase
II). An enzyme group that hydrolyzes the imidazole ring of GTP, releasing carbon-8
as formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized. This
is the first step in the synthesis of folic acid from GTP. EC 3.5.4.16 (GTP cyclohydrolase
I) and EC 3.5.4.25 (GTP cyclohydrolase II).;
MeSH synonym : 8-formylhydrolase, gtp; gtp 8-formylhydrolase; gtp ring opening enzyme; 7,8 dihydroneopterintriphosphate synthetase; gtp 8 formylhydrolase; gtp ring-opening enzyme; gtp dihydrolase; dihydrolase, gtp; 7,8-dihydroneopterintriphosphate synthetase; synthetase, 7,8-dihydroneopterintriphosphate; ring-opening enzyme, gtp; cyclohydrolase, gtp;
MeSH hyponym : GTP Cyclohydrolase I; GTP Cyclohydrolase II; Cyclohydrolase II, GTP; Cyclohydrolase I, GTP;
MeSH CAS label : GTP 7,8-8,9-dihydrolase;
Registry Number MeSH : EC 3.5.4.16;
Is substance : O;
UNII : EC 3.5.4.16;
Origin ID : D006136;
UMLS CUI : C0018293;
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(GTP cyclohydrolase I) or GTP 7,8-8,9-dihydrolase (pyrophosphate-forming) (GTP cyclohydrolase
II). An enzyme group that hydrolyzes the imidazole ring of GTP, releasing carbon-8
as formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized. This
is the first step in the synthesis of folic acid from GTP. EC 3.5.4.16 (GTP cyclohydrolase
I) and EC 3.5.4.25 (GTP cyclohydrolase II).
