ferrochelatase

Preferred Label : ferrochelatase;

MeSH definition : A mitochondrial enzyme found in a wide variety of cells and tissues. It is the final enzyme in the 8-enzyme biosynthetic pathway of HEME. Ferrochelatase catalyzes ferrous insertion into protoporphyrin IX to form protoheme or heme. Deficiency in this enzyme results in ERYTHROPOIETIC PROTOPORPHYRIA.;

MeSH synonym : Protoheme Ferro-Lyase; porphyrin-metal chelatase; heme synthetase; synthetase, heme; porphyrin metal chelatase; ferro-lyase, protoheme; chelatase, porphyrin-metal; protoheme ferro lyase;

MeSH hyponym : zinc chelatase; Chelatase, Zinc;

CISMeF hyponym : EC 4.99.1.1;

MeSH CAS label : protoheme ferro-lyase;

MeSH Related Number : zinc chelatase; 9012-93-5 (CAS RN); EC 4.99.1.1;

Registry Number MeSH : EC 4.99.1.1;

Related CAS MeSH : EC 4.99.1.1 (Zinc chelatase);

Is substance : O;

UNII : EC 4.99.1.1;

Details

Origin ID

D005294;

UMLS CUI

C0015880;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Ferrochelatase [OMIM gene]
- ferrochelatase [ORDO Gene]
- ferrochelatase [HGNC gene]
Indexing information
- 4-dodecyl-3,5-diethoxycarbonyl-1,4-dihydro-2,6-dimethylpyridine [MeSH Supplementary Concept]
- N-methylprotoporphyrin dimethyl ester [MeSH Supplementary Concept]
Record concept(s)
- ferrochelatase [MeSH concept]
- zinc chelatase [MeSH concept]
Related MeSH Supplementary Concept(s)
- AT2G30390 protein, Arabidopsis [MeSH Supplementary Concept]
- FC1 protein, Arabidopsis [MeSH Supplementary Concept]
- FECH protein, human [MeSH Supplementary Concept]
- MET8 protein, S cerevisiae [MeSH Supplementary Concept]
Related MeSH term(s)
- protoporphyria, erythropoietic [MeSH Descriptor]
See also
- protoporphyria, erythropoietic [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Ferrochelatase [LOINC component]
- Ferrochelatase (substance) [SNOMED CT concept]
- ferrochelatase [SNOMED Notion]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients