Preferred Label : dosage compensation, genetic;
MeSH definition : Genetic mechanisms that allow GENES to be expressed at a similar level irrespective
of their GENE DOSAGE. This term is usually used in discussing genes that lie on the
SEX CHROMOSOMES. Because the sex chromosomes are only partially homologous, there
is a different copy number, i.e., dosage, of these genes in males vs. females. In
DROSOPHILA, dosage compensation is accomplished by hypertranscription of genes located
on the X CHROMOSOME. In mammals, dosage compensation of X chromosome genes is accomplished
by random X CHROMOSOME INACTIVATION of one of the two X chromosomes in the female.;
MeSH synonym : gene dosage compensation; dosage compensation, gene; compensation, genetic dosage; compensation, dosage (genetics); compensation, gene dosage; genetic dosage compensation; gene dosage compensations; genetic dosage compensations; dosage compensation (genetics);
MeSH hyponym : X-Chromosome hypertranscription; X Chromosome Hypertranscription; Hypertranscription, X-Chromosome; Hypertranscription, X Chromosome;
MeSH annotation : do not confuse with GENE DOSAGE;
Origin ID : D004303;
UMLS CUI : C0013057;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Indexing information
- Record concept(s)
- Semantic type(s)
- UMLS correspondences (same concept)
Genetic mechanisms that allow GENES to be expressed at a similar level irrespective
of their GENE DOSAGE. This term is usually used in discussing genes that lie on the
SEX CHROMOSOMES. Because the sex chromosomes are only partially homologous, there
is a different copy number, i.e., dosage, of these genes in males vs. females. In
DROSOPHILA, dosage compensation is accomplished by hypertranscription of genes located
on the X CHROMOSOME. In mammals, dosage compensation of X chromosome genes is accomplished
by random X CHROMOSOME INACTIVATION of one of the two X chromosomes in the female.
