Preferred Label : DNA restriction enzymes;
MeSH definition : Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic
cleavage of DNA sequences which lack the species-specific methylation pattern in the
host cell's DNA. Cleavage yields random or specific double-stranded fragments with
terminal 5'-phosphates. The function of restriction enzymes is to destroy any foreign
DNA that invades the host cell. Most have been studied in bacterial systems, but a
few have been found in eukaryotic organisms. They are also used as tools for the systematic
dissection and mapping of chromosomes, in the determination of base sequences of DNAs,
and have made it possible to splice and recombine genes from one organism into the
genome of another. EC 3.21.1.;
MeSH synonym : restriction endonuclease; dna restriction enzyme; restriction enzyme, dna; endonuclease, restriction; endonucleases, restriction; enzymes, dna restriction; restriction endonucleases; restriction enzymes, dna;
Wikipedia automatic translation : Restriction enzyme;
Registry Number MeSH : EC 3.1.21.-;
MeSH annotation : DNA restriction enzyme used as a DNA marker: coord probably NIM with GENETIC MARKER
(IM);
Wikipedia link : https://en.wikipedia.org/wiki/Restriction enzyme;
Is substance : O;
Origin ID : D004262;
UMLS CUI : C0012906;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- See also
- Semantic type(s)
- UMLS correspondences (same concept)
Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic
cleavage of DNA sequences which lack the species-specific methylation pattern in the
host cell's DNA. Cleavage yields random or specific double-stranded fragments with
terminal 5'-phosphates. The function of restriction enzymes is to destroy any foreign
DNA that invades the host cell. Most have been studied in bacterial systems, but a
few have been found in eukaryotic organisms. They are also used as tools for the systematic
dissection and mapping of chromosomes, in the determination of base sequences of DNAs,
and have made it possible to splice and recombine genes from one organism into the
genome of another. EC 3.21.1.
