debrisoquin - CISMeF

Preferred Label : debrisoquin;

MeSH definition : An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.;

MeSH synonym : debrisoquine;

MeSH hyponym : tendor;

MeSH CAS label : 2(1H)-Isoquinolinecarboximidamide, 3,4-dihydro-;

MeSH Related Number : 1131-64-2 (Debrisoquin);

Registry Number MeSH : 1131-64-2;

Wikipedia link : https://en.wikipedia.org/wiki/Debrisoquine;

Codes EINECS : 214-470-1;

Is substance : O;

UNII : X31CDK040E;

InChIKey : JWPGJSVJDAJRLW-UHFFFAOYSA-N;

Details

Origin ID

D003647;

UMLS CUI

C0011082;

ATC code(s)
- debrisoquine [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Debrisoquine [ICHI extension code]
CISMeF manual mappings
- debrisoquin [Substance BNPC]
Currated CISMeF NLP mapping
- Debrisoquin [NCIt concept]
- Debrisoquine [ICD-11 Extension code]
- Debrisoquine (substance) [SNOMED CT concept]
Pharmacological action(s)
- adrenergic agents [MeSH Descriptor]
- antihypertensive agents [MeSH Descriptor]
- peripheral nervous system agents [MeSH Descriptor]
- sympatholytics [MeSH Descriptor]
Record concept(s)
- debrisoquin [MeSH concept]
- tendor [MeSH concept]
Related MeSH Supplementary Concept(s)
- 3,4-dehydrodebrisoquine [MeSH Supplementary Concept]
- 4-hydroxydebrisoquin [MeSH Supplementary Concept]
- 8-hydroxydebrisoquin [MeSH Supplementary Concept]
- N-hydroxydebrisoquine [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Product containing debrisoquine (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Debrisoquin [NCIt concept]
- Debrisoquine [ICD-11 Extension code]
- Debrisoquine (substance) [SNOMED CT concept]
- Product containing debrisoquine (medicinal product) [SNOMED CT concept]
- debrisoquin [Substance BNPC]
- debrisoquine [ATC Code]
Validated automatic mappings to BTNT
- debrisoquine [ATC Code]

Keyword's position in hierarchy(ies) :

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