" /> complement C3 nephritic factor - CISMeF





Preferred Label : complement C3 nephritic factor;

MeSH definition : An IgG autoantibody against the ALTERNATIVE PATHWAY C3 CONVERTASE, found in serum of patients with MESANGIOCAPILLARY GLOMERULONEPHRITIS. The binding of this autoantibody to C3bBb stabilizes the enzyme thus reduces the actions of C3b inactivators (COMPLEMENT FACTOR H; COMPLEMENT FACTOR I). This abnormally stabilized enzyme induces a continuous COMPLEMENT ACTIVATION and generation of C3b thereby promoting the assembly of MEMBRANE ATTACK COMPLEX and cytolysis.;

MeSH synonym : c3 nephritic factor; complement 3 nephritic factor; c 3 nephritic factor; C3 NeF IgG Autoantibody; C3NeF IgG Autoantibodies; C3NeF IgG Autoantibody; Autoantibody, C3NeF IgG; IgG Autoantibody, C3NeF; C3 NeF; C3 NeF IgG Autoantibodies;

Is substance : O;

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An IgG autoantibody against the ALTERNATIVE PATHWAY C3 CONVERTASE, found in serum of patients with MESANGIOCAPILLARY GLOMERULONEPHRITIS. The binding of this autoantibody to C3bBb stabilizes the enzyme thus reduces the actions of C3b inactivators (COMPLEMENT FACTOR H; COMPLEMENT FACTOR I). This abnormally stabilized enzyme induces a continuous COMPLEMENT ACTIVATION and generation of C3b thereby promoting the assembly of MEMBRANE ATTACK COMPLEX and cytolysis.

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06/07/2025


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