complement C3 nephritic factor

Preferred Label : complement C3 nephritic factor;

MeSH definition : An IgG autoantibody against the ALTERNATIVE PATHWAY C3 CONVERTASE, found in serum of patients with MESANGIOCAPILLARY GLOMERULONEPHRITIS. The binding of this autoantibody to C3bBb stabilizes the enzyme thus reduces the actions of C3b inactivators (COMPLEMENT FACTOR H; COMPLEMENT FACTOR I). This abnormally stabilized enzyme induces a continuous COMPLEMENT ACTIVATION and generation of C3b thereby promoting the assembly of MEMBRANE ATTACK COMPLEX and cytolysis.;

MeSH synonym : c3 nephritic factor; complement 3 nephritic factor; c 3 nephritic factor; C3 NeF IgG Autoantibody; C3NeF IgG Autoantibodies; C3NeF IgG Autoantibody; Autoantibody, C3NeF IgG; IgG Autoantibody, C3NeF; C3 NeF; C3 NeF IgG Autoantibodies;

Is substance : O;

Details

Origin ID

D003178;

UMLS CUI

C0009508;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- C3 nephritic factor [LOINC component]
- Complement C3 nephritic factor (substance) [SNOMED CT concept]
Pharmacological action(s)
- complement inactivating agents [MeSH Descriptor]
Record concept(s)
- complement C3 nephritic factor [MeSH concept]
See also inter- (CISMeF)
- C3 nephritic factor positivity [HPO term]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- C3 nephritic factor [LOINC component]
- Complement C3 nephritic factor (substance) [SNOMED CT concept]

Keyword's position in hierarchy(ies) :

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