complement pathway, classical

Preferred Label : complement pathway, classical;

MeSH definition : Complement activation initiated by the binding of COMPLEMENT C1 to ANTIGEN-ANTIBODY COMPLEXES at the COMPLEMENT C1Q subunit. This leads to the sequential activation of COMPLEMENT C1R and COMPLEMENT C1S subunits. Activated C1s cleaves COMPLEMENT C4 and COMPLEMENT C2 forming the membrane-bound classical C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.;

MeSH synonym : classical complement pathway; complement activation pathway, classical; classical complement activation pathway;

Details

Origin ID

D003171;

UMLS CUI

C0009547;

Allowable qualifiers
- drug effects [MeSH Qualifier]
- ethics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- immunology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Complement activation classic pathway, function (observable entity) [SNOMED CT concept]
- complement activation classic pathway, nos [SNOMED Notion]
- complement activation, classical pathway [GO term]
Currated CISMeF NLP mapping
- Classical Complement Pathway [NCIt concept]
Record concept(s)
- complement pathway, classical [MeSH concept]
Semantic type(s)
- Molecular Function [UMLS semantic type]
UMLS correspondences (same concept)
- Classical Complement Pathway [NCIt concept]

Keyword's position in hierarchy(ies) :

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