complement pathway, alternative

Preferred Label : complement pathway, alternative;

MeSH definition : Complement activation initiated by the interaction of microbial ANTIGENS with COMPLEMENT C3B. When COMPLEMENT FACTOR B binds to the membrane-bound C3b, COMPLEMENT FACTOR D cleaves it to form alternative C3 CONVERTASE (C3BBB) which, stabilized by COMPLEMENT FACTOR P, is able to cleave multiple COMPLEMENT C3 to form alternative C5 CONVERTASE (C3BBB3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.;

MeSH synonym : complement activation pathway, alternative; properdin pathway; alternative complement activation pathway; alternative complement pathway;

Details

Origin ID

D003170;

UMLS CUI

C0009546;

Allowable qualifiers
- drug effects [MeSH Qualifier]
- ethics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- immunology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Complement activation alternative pathway, function (observable entity) [SNOMED CT concept]
- complement activation alternative pathway, nos [SNOMED Notion]
- complement activation, alternative pathway [GO term]
Currated CISMeF NLP mapping
- Alternative Complement Pathway [NCIt concept]
Indexing information
- ACPIP protein, bombyx mori [MeSH Supplementary Concept]
- M161 antigen [MeSH Supplementary Concept]
- complestatin [MeSH Supplementary Concept]
- low molecular weight inhibitor (complement) [MeSH Supplementary Concept]
Record concept(s)
- complement pathway, alternative [MeSH concept]
Semantic type(s)
- Molecular Function [UMLS semantic type]
UMLS correspondences (same concept)
- Alternative Complement Pathway [NCIt concept]
- Complement activation alternative pathway, function (observable entity) [SNOMED CT concept]
- complement activation alternative pathway, nos [SNOMED Notion]
- complement activation, alternative pathway [GO term]

Keyword's position in hierarchy(ies) :

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