MeSH definition : Serologic tests based on inactivation of complement by the antigen-antibody complex
(stage 1). Binding of free complement can be visualized by addition of a second antigen-antibody
system such as red cells and appropriate red cell antibody (hemolysin) requiring complement
for its completion (stage 2). Failure of the red cells to lyse indicates that a specific
antigen-antibody reaction has taken place in stage 1. If red cells lyse, free complement
is present indicating no antigen-antibody reaction occurred in stage 1.;
Serologic tests based on inactivation of complement by the antigen-antibody complex
(stage 1). Binding of free complement can be visualized by addition of a second antigen-antibody
system such as red cells and appropriate red cell antibody (hemolysin) requiring complement
for its completion (stage 2). Failure of the red cells to lyse indicates that a specific
antigen-antibody reaction has taken place in stage 1. If red cells lyse, free complement
is present indicating no antigen-antibody reaction occurred in stage 1.