5-aminolevulinate synthetase

Preferred Label : 5-aminolevulinate synthetase;

MeSH definition : An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis. In liver feedback is inhibited by heme. EC 2.3.1.37.;

MeSH synonym : 5-aminolevulinate synthase; synthase, 5-aminolevulinate; aminolevulinic acid synthetase; synthetase, aminolevulinic acid; acid synthetase, delta-aminolevulinic; delta aminolevulinic acid synthetase; acid synthetase, aminolevulinic; delta aminolevulinate synthase; delta-aminolevulinate synthase; delta-aminolevulinic acid synthetase; synthetase, delta-aminolevulinic acid; 5 aminolevulinate synthase; synthetase, 5-aminolevulinate; synthase, delta-aminolevulinate; 5 aminolevulinate synthetase;

MeSH CAS label : Succinyl-CoA:glycine C-Succinyltransferase (decarboxylating);

MeSH Related Number : 9037-14-3 (CAS RN);

Registry Number MeSH : EC 2.3.1.37;

Is substance : O;

UNII : EC 2.3.1.37;

Details

Origin ID

D000624;

UMLS CUI

C0002565;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- 5-aminolevulinate synthase [SNOMED Notion]
- 5-aminolevulinate synthase (substance) [SNOMED CT concept]
- 5-aminolevulinate synthase activity [GO term]
Record concept(s)
- 5-Aminolevulinate synthetase [MeSH concept]
Related MeSH Supplementary Concept(s)
- ALAS1 protein, human [MeSH Supplementary Concept]
- ALAS2 protein, human [MeSH Supplementary Concept]
- ALAS2 protein, mouse [MeSH Supplementary Concept]
- aminolevulinate synthase, S cerevisiae [MeSH Supplementary Concept]
- protoporphyria, erythropoietic, X-Linked dominant [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- 5-aminolevulinate synthase [SNOMED Notion]
- 5-aminolevulinate synthase (substance) [SNOMED CT concept]

Keyword's position in hierarchy(ies) :

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