Preferred Label : Nudix Hydrolases;
MeSH definition : A group of Mg2 /Mn2 -dependent mainly pyrophosphohydrolases that hydrolyzes structures
of NUcleoside DIphosphate linked to another moiety X to nucleoside monophosphate and
X-Phosphate. Nudix hydrolases share conserved Nudix box (GX5EX7REUXEEXGU) and degrade
variety of substrates including oxidized nucleotides (e.g., MutT) and metabolic intermediates
(e.g., THIAMINE PYROPHOSPHATASE). In humans, Nudix superfamily proteins such as MutT
proteins participate in DNA damage repairs. Mutations on a nudix hydrolase (NUDT15)
are associated with a PURINE-PYRIMIDINE METABOLISM, INBORN ERRORS disorder called
THPM2, and mutations in nudix hydrolase (NUDT2) are associated with IDDPN, a developmental
intellectual disorder.;
MeSH synonym : Nudix Proteins; Nucleoside Diphosphates-Linked to Moiety-X Hydrolases; Nucleoside Diphosphates Linked to Moiety X Hydrolases; Nudix Hydrolase; Hydrolase, Nudix;
Registry Number MeSH : EC 3.6.1.-;
Origin ID : D000096964;
UMLS CUI : C5828381;
Allowable qualifiers
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- Semantic type(s)
A group of Mg2 /Mn2 -dependent mainly pyrophosphohydrolases that hydrolyzes structures
of NUcleoside DIphosphate linked to another moiety X to nucleoside monophosphate and
X-Phosphate. Nudix hydrolases share conserved Nudix box (GX5EX7REUXEEXGU) and degrade
variety of substrates including oxidized nucleotides (e.g., MutT) and metabolic intermediates
(e.g., THIAMINE PYROPHOSPHATASE). In humans, Nudix superfamily proteins such as MutT
proteins participate in DNA damage repairs. Mutations on a nudix hydrolase (NUDT15)
are associated with a PURINE-PYRIMIDINE METABOLISM, INBORN ERRORS disorder called
THPM2, and mutations in nudix hydrolase (NUDT2) are associated with IDDPN, a developmental
intellectual disorder.
