MeSH definition : Medium sized, inhibitory GABAergic neurons in the CORPUS STRIATUM with highly developed
dendritic trees. They are divided into neurons expressing DOPAMINE D1 RECEPTORS which
project preferentially to the SUBSTANTIA NIGRA PARS RETICULATA and neurons expressing
DOPAMINE D2 RECEPTORS which project preferentially to the lateral part of the GLOBUS
PALLIDUS. Medium spiny neurons are preferentially lost in HUNTINGTON DISEASE.;
MeSH synonym : Medium Spiny Neuron; Neuron, Medium Spiny; Striatal Medium-Sized Spiny Neurons; Striatal Medium Sized Spiny Neurons;
Medium sized, inhibitory GABAergic neurons in the CORPUS STRIATUM with highly developed
dendritic trees. They are divided into neurons expressing DOPAMINE D1 RECEPTORS which
project preferentially to the SUBSTANTIA NIGRA PARS RETICULATA and neurons expressing
DOPAMINE D2 RECEPTORS which project preferentially to the lateral part of the GLOBUS
PALLIDUS. Medium spiny neurons are preferentially lost in HUNTINGTON DISEASE.