Preferred Label : Mast Cell Activation Disorders;
MeSH definition : A spectrum of primary, secondary, and idiopathic disorders involving MAST CELLS and
characterized by an aberrant release of mast cell mediators which result in multiple
and variable inflammatory and allergic symptoms. These disorders are associated with
various mutations in tyrosine kinase KIT (PROTO-ONCOGENE PROTEINS C-KIT) and other
genes, underlying conditions, and responses to allergic or non-allergic triggers of
mast cell stimulation and degranulation such as local anesthetics, lactam antibiotics,
muscle relaxants, specific foods, environmental toxins, physical conditions such as
vibration, cold, pressure, and stress.;
MeSH synonym : Mast Cell Disease; Mast Cell Diseases; Mast-Cell Disease; Mast-Cell Diseases; Mast Cell Activation Disease;
MeSH hyponym : Clonal Mast Cell Proliferation Disorders;
Origin ID : D000090362;
UMLS CUI : C4272690;
Allowable qualifiers
- Record concept(s)
- Semantic type(s)
- Validated automatic mappings to BTNT
A spectrum of primary, secondary, and idiopathic disorders involving MAST CELLS and
characterized by an aberrant release of mast cell mediators which result in multiple
and variable inflammatory and allergic symptoms. These disorders are associated with
various mutations in tyrosine kinase KIT (PROTO-ONCOGENE PROTEINS C-KIT) and other
genes, underlying conditions, and responses to allergic or non-allergic triggers of
mast cell stimulation and degranulation such as local anesthetics, lactam antibiotics,
muscle relaxants, specific foods, environmental toxins, physical conditions such as
vibration, cold, pressure, and stress.
