Preferred Label : Defective Interfering Viruses;
MeSH definition : Naturally occurring or synthetically made defective mutant viral genomes and particles
which are incompetent in independent replication and interfere with normal VIRUS REPLICATION.
Some synthetic defective interfering genomes may stimulate INNATE IMMUNE RESPONSE
and are candidates for potential vaccine and therapeutic approaches for virus infections.;
Définition CISMeF : Defective interfering particles (DIPs), also known as defective interfering viruses,
are spontaneously generated virus mutants in which a critical portion of the particle's
genome has been lost due to defective replication or non-homologous recombination.
The mechanism of their formation is presumed to be as a result of template-switching
during replication of the viral genome, although non-replicative mechanisms involving
direct ligation of genomic RNA fragments have also been proposed. DIPs are derived
from and associated with their parent virus, and particles are classed as DIPs if
they are rendered non-infectious due to at least one essential gene of the virus being
lost or severely damaged as a result of the defection. A DIP can usually still penetrate
host cells, but requires another fully functional virus particle (the 'helper' virus)
to co-infect a cell with it, in order to provide the lost factors (source https://en.wikipedia.org/wiki/Defective_interfering_par).;
MeSH synonym : Defective Interfering Virus; Interfering Virus, Defective; Virus, Defective Interfering; Defective Interfering Particles; Defective Interfering Particle; Interfering Particle, Defective; Particle, Defective Interfering;
CISMeF acronym : DIP;
MeSH hyponym : Synthetic Defective Interfering Particles; Synthetic Defective Interfering Virus; Synthetic Defective Interfering Genome Viruses;
Related MeSH term : Defective Interfering Genomes; Genome, Defective Interfering; Interfering Genome, Defective;
Origin ID : D000089783;
UMLS CUI : C5544413;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Record concept(s)
- Semantic type(s)
- Virus [UMLS semantic type]
Naturally occurring or synthetically made defective mutant viral genomes and particles
which are incompetent in independent replication and interfere with normal VIRUS REPLICATION.
Some synthetic defective interfering genomes may stimulate INNATE IMMUNE RESPONSE
and are candidates for potential vaccine and therapeutic approaches for virus infections.
Defective interfering particles (DIPs), also known as defective interfering viruses,
are spontaneously generated virus mutants in which a critical portion of the particle's
genome has been lost due to defective replication or non-homologous recombination.
The mechanism of their formation is presumed to be as a result of template-switching
during replication of the viral genome, although non-replicative mechanisms involving
direct ligation of genomic RNA fragments have also been proposed. DIPs are derived
from and associated with their parent virus, and particles are classed as DIPs if
they are rendered non-infectious due to at least one essential gene of the virus being
lost or severely damaged as a result of the defection. A DIP can usually still penetrate
host cells, but requires another fully functional virus particle (the 'helper' virus)
to co-infect a cell with it, in order to provide the lost factors (source https://en.wikipedia.org/wiki/Defective_interfering_par).
