Preferred Label : Extranodal Extension;
MeSH definition : A penetration of LYMPH NODE metastatic cells through the nodal capsule into the perinodal
fatty tissue used in a TUMOR STAGING system (the TNM staging system).;
Définition CISMeF : Extranodal extension refers to the growth of a nodal cancer metastasis beyond the
confines of the capsule of a lymph node into adjacent tissues. Less preferred synonyms
include extranodal spread, extracapsular extension, or extracapsular spread. This
finding holds prognostic implications. For example, in the latest TNM staging system
for most cancers of the head and neck, extranodal extension is the most significant
pathological finding in a positive lymph node. For staging purposes, a regional node
metastasis invading a distant organ is considered an extranodal extension and not
distant metastatic disease.;
MeSH synonym : Extracapsular Extension;
Related MeSH term : Extranodal Tumor Deposit; Tumor Deposit, Extranodal; Tumor Deposit; Tumor Deposits;
Origin ID : D000079822;
UMLS CUI : C3899187;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Record concept(s)
- Semantic type(s)
- UMLS correspondences (same concept)
A penetration of LYMPH NODE metastatic cells through the nodal capsule into the perinodal
fatty tissue used in a TUMOR STAGING system (the TNM staging system).
Extranodal extension refers to the growth of a nodal cancer metastasis beyond the
confines of the capsule of a lymph node into adjacent tissues. Less preferred synonyms
include extranodal spread, extracapsular extension, or extracapsular spread. This
finding holds prognostic implications. For example, in the latest TNM staging system
for most cancers of the head and neck, extranodal extension is the most significant
pathological finding in a positive lymph node. For staging purposes, a regional node
metastasis invading a distant organ is considered an extranodal extension and not
distant metastatic disease.
