Niemann-Pick C1 Protein

Preferred Label : Niemann-Pick C1 Protein;

MeSH definition : A transmembrane intracellular lipid transporter that helps trafficking lipids, particularly cholesterol, from late endosome/lysosome to the ER and plasma membrane. It may also play a role in other cellular cholesterol homeostasis and is an endosomal entry receptor for filoviruses including EBOLAVIRUS. Mutations in the NPC1 are associated with type C NIEMANN-PICK DISEASE.;

MeSH synonym : Niemann Pick C1 Protein; NPC1 Protein;

Details

Origin ID

D000077296;

UMLS CUI

C4704754;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- physiology [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
Record concept(s)
- Niemann-Pick C1 Protein [MeSH concept]
Related MeSH Supplementary Concept(s)
- NPC1 protein, human [MeSH Supplementary Concept]
- NPC1 protein, rat [MeSH Supplementary Concept]
- NPC1 protein, zebrafish [MeSH Supplementary Concept]
- Npc1 protein, mouse [MeSH Supplementary Concept]
- Npc1a protein, Drosophila [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients