WNK Lysine-Deficient Protein Kinase 1

Preferred Label : WNK Lysine-Deficient Protein Kinase 1;

MeSH definition : A serine-threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. It functions as an activator and inhibitor of sodium-coupled chloride co-transporters and as an inhibitor of potassium-coupled chloride co-transporters. Mutations in the WNK1 gene are associated with type 2C PSEUDOHYPOALDOSTERONISM and type 2A HEREDITARY SENSORY AND AUTONOMIC NEUROPATHIES.;

MeSH synonym : WNK Lysine Deficient Protein Kinase 1;

Registry Number MeSH : EC 2.7.11.1;

UNII : EC 2.7.11.1;

Details

Origin ID

D000076204;

UMLS CUI

C4319716;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- WNK lysine deficient protein kinase 1 [ORDO Gene]
- WNK lysine deficient protein kinase 1 [HGNC gene]
Record concept(s)
- WNK Lysine-Deficient Protein Kinase 1 [MeSH concept]
Related MeSH Supplementary Concept(s)
- WNK1 protein, arabidopsis [MeSH Supplementary Concept]
- WNK1 protein, human [MeSH Supplementary Concept]
- Wnk1 protein, mouse [MeSH Supplementary Concept]
- Wnk1 protein, rat [MeSH Supplementary Concept]
- wnk-1 protein, C elegans [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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