Preferred Label : Nedd4 Ubiquitin Protein Ligases;
MeSH definition : E3 ubiquitin ligases that consist of four WW DOMAINS. They accept UBIQUITIN from E2
UBIQUITIN-CONJUGATING ENZYME as a thioester via their C-terminal HECT domains and
transfer it specifically to the 63rd LYSINE residue (Lys-63) of target proteins. NEDD4
targets include many proteins and receptors with important functions for cell growth
and homeostasis such as VEGFR-2; FGFR1 TYROSINE KINASE; and ERBB-4 RECEPTOR. They
play a critical role in the internalization of these receptors, their degradation
by LYSOSOMES, and also function as part of the ESCRT complex in VIRUS RELEASE.;
E3 ubiquitin ligases that consist of four WW DOMAINS. They accept UBIQUITIN from E2
UBIQUITIN-CONJUGATING ENZYME as a thioester via their C-terminal HECT domains and
transfer it specifically to the 63rd LYSINE residue (Lys-63) of target proteins. NEDD4
targets include many proteins and receptors with important functions for cell growth
and homeostasis such as VEGFR-2; FGFR1 TYROSINE KINASE; and ERBB-4 RECEPTOR. They
play a critical role in the internalization of these receptors, their degradation
by LYSOSOMES, and also function as part of the ESCRT complex in VIRUS RELEASE.
Allowable qualifiers