MeSH definition : Drug formulations or delivery systems intended to discourage the abuse of CONTROLLED
SUBSTANCES. These may include physical barriers to prevent chewing or crushing the
drug; chemical barriers that prevent extraction of psychoactive ingredients; agonist-antagonist
combinations to reduce euphoria associated with abuse; aversion, where controlled
substances are combined with others that will produce an unpleasant effect if the
patient manipulates the dosage form or exceeds the recommended dose; delivery systems
that are resistant to abuse such as implants; or combinations of these methods.;
Drug formulations or delivery systems intended to discourage the abuse of CONTROLLED
SUBSTANCES. These may include physical barriers to prevent chewing or crushing the
drug; chemical barriers that prevent extraction of psychoactive ingredients; agonist-antagonist
combinations to reduce euphoria associated with abuse; aversion, where controlled
substances are combined with others that will produce an unpleasant effect if the
patient manipulates the dosage form or exceeds the recommended dose; delivery systems
that are resistant to abuse such as implants; or combinations of these methods.
Allowable qualifiers