MeSH definition : A deubiquitinase and tumor-suppressor protein that specifically cleaves LYSINE-63-linked
polyubiquitin chains and also has endodeubiquitinase activity. It functions to regulate
NF-KAPPA B and WNT SIGNALING PATHWAY activity, contributing to cell survival, proliferation,
and differentiation. Mutations in the CYLD gene are associated with cases of FAMILIAL
CYLINDROMATOSIS.;
A deubiquitinase and tumor-suppressor protein that specifically cleaves LYSINE-63-linked
polyubiquitin chains and also has endodeubiquitinase activity. It functions to regulate
NF-KAPPA B and WNT SIGNALING PATHWAY activity, contributing to cell survival, proliferation,
and differentiation. Mutations in the CYLD gene are associated with cases of FAMILIAL
CYLINDROMATOSIS.
Allowable qualifiers