Preferred Label : Dual Oxidases;
MeSH definition : NADPH oxidases that contain two additional EF HAND MOTIFS and an N-terminal PEROXIDASE
domain. They are expressed by THYROCYTES and EPITHELIAL CELLS of the kidney, liver,
trachea, lung, and glandular tissues such as the testis, pancreas, and prostate. They
are critical for the activity of THYROID PEROXIDASE and play a role in the production
of thyroid hormones; they may also have antimicrobial activity through the generation
of REACTIVE OXYGEN SPECIES.;
MeSH synonym : Oxidases, Dual; Duox Proteins; Proteins, Duox; Dual Oxidase; Oxidase, Dual;
DeCS synonym : Dual Oxidase 1; Dual Oxidase 2;
MeSH hyponym : Oxidase 1, Dual; DUOX1; Oxidase 2, Dual; NADPH Thyroid Oxidase 2; Thyroid Oxidase 2; Oxidase 2, Thyroid; DUOX2;
MeSH Related Number : EC 1.6.3.1;
Registry Number MeSH : EC 1.11.1.-;
Origin ID : D000074623;
UMLS CUI : C4505256;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- Semantic type(s)
NADPH oxidases that contain two additional EF HAND MOTIFS and an N-terminal PEROXIDASE
domain. They are expressed by THYROCYTES and EPITHELIAL CELLS of the kidney, liver,
trachea, lung, and glandular tissues such as the testis, pancreas, and prostate. They
are critical for the activity of THYROID PEROXIDASE and play a role in the production
of thyroid hormones; they may also have antimicrobial activity through the generation
of REACTIVE OXYGEN SPECIES.
